Navigating Long-Term Toxicities of CAR T-Cell Therapy: Educational Insights for Oncology Pharmacists

A PTCE virtual symposium affiliated with the 2024 HOPA Annual Conference.

Program Description

Early recognition and treatment of cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) is central to ensuring optimal outcomes in patients receiving chimeric antigen receptor (CAR) T-cell therapy. These early-onset adverse effects of CAR T-cell therapy are well-defined and recognizable in clinical practice. However, the long-term adverse effects of CAR T-cell therapy, such as hypogammaglobulinemia, delayed-onset neurotoxicity, secondary malignancies, immune effector cell–associated hematotoxicity (ICAHT), and infections, are emerging concerns. This program will educate oncology pharmacists on the risks, signs, and symptoms of long-term toxicities associated with CAR T-cell therapy, as well as emerging data regarding appropriate monitoring and follow-up approaches to ensure timely and effective management, customized treatment strategies, and overall long-term safety for patients.

Target audience: Oncology pharmacists

Type of activity: Application
Release date: June 4, 2024
Expiration date: June 4, 2025

Time to complete activity: 1.25 hours

Learner level: Advanced
Fee: Free

Educational Objectives

At the completion of this activity, participants will be able to:

• Identify risk factors contributing to long-term toxicities in patients undergoing chimeric antigen receptor (CAR) T-cell therapy
• Differentiate the presentation patterns of short-term and long-term toxicities in CAR T-cell therapy, considering factors such as onset, symptoms, and clinical manifestations
• Employ strategies to assess, monitor, and mitigate long-term toxicities in patients receiving CAR T-cell therapy

Pharmacy Times Continuing Education™ is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 1.25 contact hours (0.125 CEU) under the ACPE universal activity number 0290-0000-24-173-H01-P. The activity is available for CE credit through June 4, 2025.

Instructions for Completing the Activity and Receiving CPE Credit

To receive CPE credit, participants must complete the pretest, review the activity in its entirety, complete the posttest, and complete the online activity evaluation. After successful completion of the online activity evaluation, you can submit your credit to CPE Monitor. You may view your credit within 48 hours at www.mycpemonitor.net. All participants must request credit before the activity expiration date. CE credit will not be issued after this date.

Mary McGann, PharmD, BCOP, has the following financial relationship with a commercial interest to disclose:

Consultant: Sanofi - advisory board for Rezurock (cGVHD)

Katie S. Gatwood, PharmD, BCOP, has the following financial relationships with commercial interests to disclose:

Consultant: BioLine Rx, Astellas, Sanofi

Speakers Bureau: Sanofi, Kite Pharma, Jazz Pharmaceuticals, BioLine Rx

Pharmacy Times Continuing Education^™ Planning Staff—Jim Palatine, RPh, MBA; Amy L. Morris, PharmD, BCOP; Aleksandra Thomas; Susan Pordon; Brianna Winters; Chloe Taccetta; and Rebecca Green have no relevant financial relationships with commercial interests to disclose.

Anonymous peer reviewers were used as part of content validation and conflict resolution. The peer reviewers have no relevant financial relationships with commercial interests to disclose.

Educational Disclaimer
CPE activities are offered solely for educational purposes and do not constitute any form of professional advice or referral. Discussions concerning drugs, dosages, and procedures may reflect the clinical experience of the author(s) or they may be derived from the professional literature or other sources and may suggest uses that are investigational in nature and not approved labeling or indications. Participants are encouraged to refer to primary references or full prescribing information resources.

For questions about this internet CPE activity, please contact:
[email protected]
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