A Pharmacologic Overview of Antibody-Drug Conjugates

This activity includes animation videos. 

Program Description

Antibody-drug conjugates (ADCs) have emerged as therapeutic agents in the treatment of multiple cancer types. Though clinical data have shown favorable and improved outcomes with ADCs across malignancies, they have also been associated with acquired resistance and unique toxicity profiles. As additional ADCs enter the treatment paradigm for patients with solid tumors, oncology pharmacists must be prepared to mitigate and manage adverse effects while supporting the appropriate preparation, dispensing, and administration of ADCs. This article will also explore the pharmacologic properties of ADCs affecting their mechanism of action, efficacy, and toxicity profiles.

Target audience: Oncology pharmacists

Type of activity: Application
Release date: April 28, 2023
Expiration date: June 15, 2024

Time to complete activity: 2.0 hours

Learner level: Foundational
Fee: Free

Educational Objectives

At the completion of this activity, participants will be able to:

• Explore the relationship between structure and function of antibody-drug conjugates (ADCs)
• Examine the differences in pharmacologic parameters among ADCs approved for the treatment of solid tumors
• Explain administration requirements and monitoring considerations of ADCs
• Optimize outpatient care of patients receiving ADCs through pharmacist-directed initiatives

Pharmacy Times Continuing Education™ is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 2.0 contact hours (0.20 CEU) under the ACPE universal activity number 0290-0000-23-180-H01-P. The activity is available for CE credit through June 15, 2024.

Instructions for Completing the Activity and Receiving CPE Credit

To receive CPE credit, participants must complete the pretest, review the activity in its entirety, complete the posttest, and complete the online activity evaluation. After successful completion of the online activity evaluation, you can submit your credit to CPE Monitor. You may view your credit within 48 hours at www.mycpemonitor.net. All participants must request credit before the activity expiration date. CE credit will not be issued after this date.

Disclosures

The following contributors have no relevant financial relationships with commercial interests to disclose:

Faculty
Allison Schepers, PharmD, BCOP

Medical Writing and Editorial Support

Krishna Patel, PharmD

Pharmacy Times Continuing Education™ Planning Staff—Jim Palatine, RPh, MBA; Amy Seung, PharmD, BCOP, FHOPA, CHCP; Amy Morris, PharmD, Crissy Wilson; Susan Pordon; Brianna Winters; and Chloe Taccetta.

An anonymous peer reviewer was used as part of content validation and conflict resolution. The peer reviewer has no relevant financial relationships with commercial interests to disclose.

Educational Disclaimer
CPE activities are offered solely for educational purposes and do not constitute any form of professional advice or referral. Discussions concerning drugs, dosages, and procedures may reflect the clinical experience of the author(s) or they may be derived from the professional literature or other sources and may suggest uses that are investigational in nature and not approved labeling or indications. Participants are encouraged to refer to primary references or full prescribing information resources.

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